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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 7, 2014; 20(33): 11574-11585
Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11574
Table 1 Main genetic and epigenetic alterations in gastric cancer tissues and their clinical application as biomarkers
AlterationType of alterationClinical applicationRef.
HER-2 amplificationGeneticPrognostic and therapeutic[34-40]
MYC amplificationGeneticProgression and metastasis[52]
TP53 Arg72ProGeneticRisk predictor, prognostic[63-67,69-72]
CDH1 -160 C>AGeneticRisk predictor[76-78]
CDH1 hypermethylationEpigeneticPrognostic, metastasis[167,170,171]
p16 hypermethylationEpigeneticDiagnostic, prognostic and therapeutic[156-160]
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