Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety

doi:10.3748/wjg.v20.i32.11422

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Gastroenterol. Aug 28, 2014; 20(32): 11422-11428
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11422

Table 2 Response rates in the subjects with irritable bowel syndrome-diarrhea for abdominal pain and diarrhea n (%)

	Arm	n	CR	PR	SR	NR	Response rate
Abdominal pain
Per protocol	A	82	22 (26.8)	21 (25.6)	27 (32.9)	12 (14.6)	43 (52.4)^a
	B	88	14 (15.9)	15 (17.0)	28 (31.8)	31 (35.2)	29 (33.0)
Intention-to-treat	A	100	22 (22)	21 (21)	27 (27)	30 (30)	43 (43)^a
	B	100	14 (14)	15 (15)	28 (28)	43 (43)	29 (29)
Diarrhea
Per protocol	A	82	25 (30.5)	25 (30.5)	23 (28)	9 (11)	50 (61.0)^b
	B	88	13 (14.8)	21 (23.9)	30 (34.1)	24 (27.3)	34 (38.6)
Intention-to-treat	A	100	25 (25)	25 (25)	23 (23)	27 (27)	50 (50)^a
	B	100	13 (13)	21 (21)	30 (30)	36 (36)	34 (34)
Abdominal pain plus diarrhea
Per protocol	A	82	24 (29.3)	28 (34.1)	21 (25.6)	9 (11)	52 (63.4)^b
	B	88	11 (12.5)	26 (29.5)	15 (17.0)	36 (40.9)	37 (42.0)
Intention-to-treat	A	100	24 (24)	28 (28)	21 (21)	27 (27)	52 (52)^a
	B	100	11 (11)	26 (26)	15 (15)	48 (48)	37 (37)

^aP < 0.05,

^bP < 0.01 vs arm B. CR: Complete response; NR: Non-response; PR: Partial response; SR: Slight response.

Citation: Lan L, Chen YL, Zhang H, Jia BL, Chu YJ, Wang J, Tang SX, Xia GD. Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety. World J Gastroenterol 2014; 20(32): 11422-11428
URL: https://www.wjgnet.com/1007-9327/full/v20/i32/11422.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i32.11422