Involvement of eicosanoids in the pathogenesis of pancreatic cancer: The roles of cyclooxygenase-2 and 5-lipoxygenase

Figure 1 Inflammatory cell infiltration into the tumor microenvironment. As pancreatic adenocarcinoma progresses, inflammatory cells such as mast cells, neutrophils, and macrophages are attracted to the tumor microenvironment and enhance tumor growth. Leukotriene B₄ (LTB₄) is a chemotactic factor for macrophages, neutrophils, and mast cells. Fibroblasts are also activated and enhance collagen production.