Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis

Table 1 Preoperative factors affecting the overall survival and tumor-free survival of hepatocellular carcinoma patients

Category	Subcategory	Overall survival			Tumor-free survival
		Univariate analysis	Multivariate analysis	HR (95%CI)	Univariate analysis	Multivariate analysis	HR (95%CI)
Gender	Male (139)	0.935			0.916
	Female (33)
Age	≥ 60 yr (55)	0.090			0.233
	< 60 yr (117)
HBV	Yes (121)	0.044	0.012	0.556	0.084
	No (51)			(0.353-0.878)
HCV	Yes (8)	0.637			0.485
	No (164)
Cirrhosis	Yes (59)	0.321			0.141
	No (113)
ALP	> 120 U/L (50)	< 0.001	0.008	1.866	< 0.001	0.002	1.973
	≤ 120 U/L(122)			(1.176-2.960)			(1.283-3.034)
GGT	> 115 U/L (48)	< 0.001	0.030	1.674	0.001	0.676
	≤ 115 U/L (124)			(1.050-2.668)
AFP	≥ 400 ng/mL (66)	0.085			0.001	0.017	1.685
	< 400 ng/mL (106)						(1.099-2.583)
Tumor characteristics
Size	≥ 5 cm (114)	< 0.001	< 0.001	4.472	< 0.001	< 0.001	4.315
	< 5 cm (58)			(2.328-8.590)			(2.299-8.099)
Number	> 1 (32)	0.143			0.218
	= 1 (140)
Invasion	Yes (54)	0.319			0.379
	No (118)
Lymphnode metastasis	Yes (6)	0.001	0.242		< 0.001	0.009	3.149
	No (166)						(1.329-7.462)

ALP: Alkaline phosphatase; GGT: γ-glutamyltransferase; AFP: α-fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus.