Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Aug 7, 2014; 20(29): 9998-10007
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9998
Table 1 Clinical studies of contrast enhanced ultrasound efficacy for liver metastases detection, in comparison with ultrasound
Ref.patients(n)Standard of referenceSensitivity
Specificity
USCEUSUSCEUS
Itabashi et al[62], 2013454PathologyIntra-operative CEUS found 71 CRLMs that were not detected at preoperative imaging
Muhi et al[60], 2011106Histology, follow up CT, SPIO/ GdEOB MRI-73--
Cantisani et al[59], 2010110IOUS, CT, follow up CT, MRI71.695.860.083.3
Larsen et al[65], 2009365Histology, follow up CT-80-98.0
Piscaglia et al[66], 2007107CT, FNA, follow up0.770.95--
Konopke et al[57], 2007100IOUS0.560.840.930.84
Larsen et al[67], 2007365FNA, CT, IOUS0.690.800.980.98
Janica et al[68], 200751CT, FNA, follow up0.630.90--
Dietrich et al[69], 2006131CT, MRI, FNA, follow up0.810.91--
Quaia et al[70], 2006253FNA, CT, MRI, IOUS0.400.830.630.84
Konopke et al[71], 200556IOUS, FNA, CT0.530.860.890.89
Oldenburg et al[72], 200540CT, MRI0.690.90--
Albrecht et al[73], 2003123CT, MRI, IOUS, FNA0.940.980.600.88
Solbiati et al[11], 200132CT-21 out of 32, 94 more metastases than US--
Bernatik et al[58], 200128CT0.590.97--
Albrecht et al[74], 200162CT, MRI, IOUS, FNA0.920.97--