Genetic predisposition to colorectal cancer: Where we stand and future perspectives

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2014; 20(29): 9828-9849
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.9828

Table 2 Clinico-pathological characteristics of Lynch syndrome

Clinico-pathological characteristics
The onset of colorectal cancer (CRC) occurs at an early age (average 45 yr)
Predilection to develop proximal (right-sided) colon cancer
High risk of multiple primary colorectal tumors (synchronous or metachronous)
Specific pathological features of lynch syndrome-related colorectal tumors:
Poorly differentiated
Mucinous
Signet-cell features
Crohn’s-like lymphocytic reaction
Excess of tumor-infiltrating lymphocytes
Increased survival (in patients with CRC)
Accelerated carcinogenesis
Increased risk of cancer at extracolonic sites:
Endometrium
Ovary
Stomach
Small bowel
Hepatobiliary tract
Pancreas
Upper uroepithelial tract
Brain (Turcot’s syndrome)
Sebaceous adenomas, carcinomas and keratoacanthomas (Muir-Torre syndrome)

Citation: Valle L. Genetic predisposition to colorectal cancer: Where we stand and future perspectives. World J Gastroenterol 2014; 20(29): 9828-9849
URL: https://www.wjgnet.com/1007-9327/full/v20/i29/9828.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i29.9828

Valle L. Genetic predisposition to colorectal cancer: Where we stand and future perspectives. World J Gastroenterol 2014; 20(29): 9828-9849 [PMID: 25110415 DOI: 10.3748/wjg.v20.i29.9828]

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