Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Table 1 Histopathological damage scores for the control and the methotrexate-exposed groups, with and without antioxidant treatments

	Control	Model	MTX + NAC	MTX + AMF	MTX + ASC
Score	1 (0-3)	7 (6-9)a	4 (3-6)b	4.5 (3-5)a	6 (5-6)acd

Data are expressed median (range).

^aP = 0.001 vs control group;

^bP = 0.001 vs control and model groups;

^cP < 0.05 vs MTX + NAC group;

^dP < 0.005 vs model and MTX + AMF groups. MTX: Methotrexate; NAC: N-acetyl cysteine; AMF: Amifostine.