Down-regulation of FoxM1 inhibits viability and invasion of gallbladder carcinoma cells, partially dependent on inducement of cellular senescence

Figure 1 Immunohistochemical analysis of Forkhead box M1 in gallbladder carcinoma (A and D), pericarcinoma (B and E) and healthy tissues (C and F). Typically, immunohistologic features showed high levels of Forkhead box M1 (FoxM1) expression in carcinoma, low levels of FoxM1 expression in pericarcinoma, and negative staining of FoxM1 in healthy gallbladder tissues. G: Kaplan-Meier analysis of the GBC patients, indicating the poorer survival of the patients with positive FoxM1 expression (P < 0.05). Original magnification (× 100, top; × 400, bottom).