Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

Table 3 Outcome predictors in patients with alcoholic liver disease and nonalcoholic fatty liver disease

Outcomes	ALD	NAFLD	Ref.
Hepatocarcinogenesis
Underlying liver disease
Compensated cirrhosis	Not identified		[90]
Decompensated cirrhosis	Older age		[91]
Compensated/decompensated cirrhosis	PNPLA3 rs738409 G	Older age, any alcohol intake	[92-94]
	Not identified	Older age, elevated GGT, high CP score	[96]
Unknown stage		Older age, type 2 diabetes, elevated AST, low PLT	[95]
Hepatic decompensation
	Persistent alcohol intake		[90]
Mortality (overall)
Underlying liver disease
Simple hepatic steatosis	Low ALB, severe steatosis	Low ALB	[55]
Simple hepatic steatosis/steatohepatitis		Older age, type 2 diabetes	[101]
Advanced fibrosis/cirrhosis	Persistent alcohol intake, older age, smoking, low ALB	AST/ALT > 1, older age	[99,100]
Compensated cirrhosis	Persistent alcohol intake		[90]
Decompensated cirrhosis	Older age, alcohol abuse, elevated ALP		[97]
	Older age, persistent alcohol intake, low ALB, high MELD score		[98]
	Older age, poor liver function		[91]
Unknown stage		Metabolic syndrome, older age, smoking, Black	[102]
	Type 2 diabetes, insulin resistance	Type 2 diabetes, insulin resistance	[103]

ALD: Alcoholic liver disease; NAFLD: Nonalcoholic fatty liver disease; ALB: Albumin; ALP: Alkaline phosphatase; MELD: Model for end-stage liver disease; GGT: γ-glutamyl transpeptidase; CP: Child-Pugh; AST: Aspartate aminotransferase; PLT: Platelet; ALT: Alanine aminotransferase.