Effect of a high-fat diet in development of colonic adenoma in an animal model

Figure 1 Experiment protocol and representative images of colonic adenomas. A: Colonic adenoma experiment protocol. Rats (4-wk-old) were divided into a normal-fat diet (ND) group (n = 10) and a high-fat diet (HFD) group (n = 10). Sixteen weeks after the start of 1,2-dimethylhydrazine (DMH) intraperitoneal injection, the rats were euthanized; B: Representative images of adenomas in colon specimens from the ND group (above) and HFD group (below) when the colons were opened longitudinally. The location of the adenomas is indicated by arrows.