Efficacy of tailored Helicobacter pylori eradication therapy based on antibiotic susceptibility and CYP2C19 genotype

Figure 1 Success of Helicobacter pylori eradication treatment as a function of pH. A, B: Median 24-h pH values (A) and the percentage of the times when pH < 4.0 during eradication therapy according to successful and failed treatment (B); C: Variation of pH and the percentage of time at pH < 4.0[51]. The median pH of successfully treated patients was significantly higher than compared with patients that failed treatment (A). The median percentage of the time when pH < 4.0 in successfully treated patients was significantly shorter compared with unsuccessfully treated patients (B). The majority of patients were cured using triple therapy when the percentage of time at pH < 4.0 during the 24-h post-dose period was < 10% and the 24-h pH was > 6.0 (shaded area) (C). CAM: Clarithromycin.