Selection of a TIPS stent for management of portal hypertension in liver cirrhosis: An evidence-based review

doi:10.3748/wjg.v20.i21.6470

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 7, 2014; 20(21): 6470-6480
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6470

Table 2 Transjugular intrahepatic portosystemic shunt for the treatment of refractory ascites: An overview of meta-analyses

Ref.	Design	No. trials	Comparative arms	Target population	Efficacy of TIPS	Encephalopathy	Survival or death
Chen et al[25]	Meta-regression and Trial Sequential Meta-analysis	6	TIPS vs large-volume paracentesis	Refractory ascites in liver cirrhosis	Ameliorate refractory ascites: TIPS was better (P < 0.05)	Frequency of HE: TIPS was higher (P < 0.01)	Overall mortality: NS; subgroup mortality (patients with better hepatic and renal function): TIPS was lower (P < 0.05)
Salerno et al[26]	Meta-analysis of individual patient data	4	TIPS vs large-volume paracentesis	Refractory ascites in liver cirrhosis	Tense ascites recurrence: TIPS was lower (P < 0.0001)	Average number of HE episodes: TIPS was higher (P = 0.006)	Transplant-free survival: TIPS was better (P = 0.035)
Saab et al[27]	Meta-analysis of RCTs	5	TIPS vs paracentesis	Refractory ascites in liver cirrhosis	Re-accumulation of ascites: TIPS was lower (P < 0.01)	Frequency of HE: TIPS was higher (P < 0.01)	30-d mortality: NS; 24-mo mortality: NS
D'Amico et al[28]	Meta-analysis of RCTs	5	TIPS vs paracentesis	Refractory ascites in liver cirrhosis	Recurrence of ascites: TIPS was lower (P < 0.05)	Frequency of HE: TIPS was higher (P < 0.05)	Mortality: NS
Albillos et al[29]	Meta-analysis of RCTs	5	TIPS vs paracentesis	Refractory ascites in liver cirrhosis	Ascites recurrence: TIPS was lower (P < 0.05)	Risk of HE: TIPS was greater	Overall mortality: NS; subgroup mortality (patients with recidivant ascites): TIPS was lower (P < 0.05)
Deltenre et al[30]	Meta-analysis of RCTs	5	TIPS vs large-volume paracentesis	Refractory ascites in liver cirrhosis	Control of ascites: TIPS was better (P < 0.001)	HE: TIPS was higher (P < 0.001)	Survival: NS

HE: Hepatic encephalopathy; NS: Not significant; RCT: Randomized controlled trial; TIPS: Transjugular intrahepatic portosystemic shunt.

Citation: Qi XS, Bai M, Yang ZP, Fan DM. Selection of a TIPS stent for management of portal hypertension in liver cirrhosis: An evidence-based review. World J Gastroenterol 2014; 20(21): 6470-6480
URL: https://www.wjgnet.com/1007-9327/full/v20/i21/6470.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i21.6470