Donor transmitted and de novo cancer after liver transplantation

Table 2 Summary of council of europe and organ procurement and transplantation network/united network for organ sharing guidelines for donor with cancer history

Council of Europe guidelines[17]: Donors with unacceptable risk of transmission
Features applicable to cancer of any histological type at any time prior to donation
Presence of metastasis - lymphatic or distant
Absence of curative surgical treatment or missed follow-up (except low-grade prostate cancer under surveillance)
Palliative therapy for cancer
Non-CNS cancer at any time prior to donation
Breast
Ovary
Choriocarcinoma
Malignant melanoma, including carcinoma-in-situ
Sarcoma
Chronic Leukaemia
Thyroid (except capsulated papillary or minimally invasive follicular type)
Non-CNS cancer diagnosed during donor procurement
All cancers, except:
Renal cell cancer < 2.5-4.0 cm (pT1a), tumour free resection margin and Fuhrman grade I or II
Localised low grade (Gleason score ≤ 6) prostate cancer
Small gastrointestinal stromal tumours
Localised non-melanoma skin cancer
Cancers of the CNS
WHO grade IV cancers
WHO grade III cancers with following features:
Presence of ventriculo-peritoneal or ventriculo-atrial shunts
Craniotomy
Systemic chemotherapy
Radiotherapy
OPTN/UNOS guidelines[18] - intermediate or high risk of transmission
Intermediate risk of transmission (1%-10%) Breast cancer, stage 0 Colon cancer, stage 0 Renal cell cancer (resected, solitary): 4-7 cm, well differentiated, stage I Treated non-CNS malignancy (≥ 5 yr prior) with cure rate 90%-99%	High risk of transmission (> 10%) Breast cancer, stage > 0 Colon cancer, stage > 0 Renal cell cancer: > 7 cm or stage II-IV Choriocarcinoma Leukaemia Lymphoma Small cell cancer: lung/neuroendocrine Metastatic carcinoma Sarcoma Lung cancer: stage I-IV Any CNS tumour with ventriculo-peritoneal or ventriculo-atrial shunt, surgery (other than uncomplicated biopsy), irradiation or extra-cranial metastases CNS tumour of WHO grade III or IV Any other cancer with insufficient follow-up or probability of cure < 90%

OPTN/UNOS: Organ Procurement and Transplantation Network/United Network for Organ Sharing Guidelines; CNS: Central nervous system; WHO: World health organization.