Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer

doi:10.3748/wjg.v20.i20.6123

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May 28, 2014 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2014; 20(20): 6123-6132
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6123

Table 1 Antibodies against mucin 1 recognizing various epitopes

Antibody	Epitope	Antigen
DF3	Core peptide sequence (DTRPAPGS) in the extracellular tandem repeat	Poorly glycosylated MUC1
NCL-MUC-1-CORE	Core peptide sequence (GVTSAPDTRPAP) in the extracellular tandem repeat	Poorly glycosylated MUC1
MY.1E12	O-linked Sialyl T1 antigen in the extracellular tandem repeat	Sialylated MUC1
NCL-MUC-1-GP	Carbohydrate in the extracellular tandem repeat	Sialylated MUC1
KL-6	Core peptide sequence (PDTRPAP) with O-linked Sialyl T¹ antigen in the extracellular tandem repeat	Sialylated MUC1
	3'-sialylated, 6'-sulfated LNnT² and 3'-sialylated, 6-sulfated T antigen³
HMFG-1	Core peptide sequence (PDTR) in the extracellular tandem repeat	Highly-glycosylated MUC1

¹Sialyl T: Neu5Acα2,3Galβ1,3GalNAc;

²3'-Sialylated, 6'-sulfated LNnT: Neu5Acα2-3(SO₃⁻-6)Galβ1-4GlcNAcβ1-3Galβ1-4Glc;

³3'-Sialylated, 6'-sulfated T: Neu5Acα2-3Galβ1-3(SO₃⁻-6)GalNAc. MUC1: Mucin 1.

Citation: Inagaki Y, Gao J, Song P, Kokudo N, Nakata M, Tang W. Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer. World J Gastroenterol 2014; 20(20): 6123-6132
URL: https://www.wjgnet.com/1007-9327/full/v20/i20/6123.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i20.6123