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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2014; 20(2): 486-497
Published online Jan 14, 2014. doi: 10.3748/wjg.v20.i2.486
Table 2 Ongoing clinical studies that analyzed targeted therapy in combination with radiofrequency ablation
Number of clinical trialsPhaseDrugPatients (n)TimingPrimary endpoint
NCT01470495Randomized studySorafenib (dose non specified)200 TRTogether with RFA continuouslyTTP
NCT00813293IISorafenib (800 mg/d)209 d before RFAEffectiveness
SORAMIC trialIISorafenib (dose non specified)1500After RFA or SIRTTime to recurrence, OS
NCT01126645
STORM trial NCT00692770IIISorafenib(800 mg/d)1114After RFA continuouslyRFS
NCT00728078II-IIIThalidomide (150 mg/d)200After RFA for 6 moPFS, morbidity