Attempts to enhance the eradication rate of Helicobacter pylori infection

Table 2 Current recommended first line regimens of Helicobacter pylori eradication

Guidelines	Regimens	Duration
Maastricht IV/Florence (2012)[6]	Clarithromycin containing treatments in areas of low clarithromycin resistance (Bismuth-containing quadruple treatment is an alternative)	7-14 d
	Bismuth-containing quadruple treatment in areas of high clarithromycin resistance (if not available, sequential treatment or non-bismuth quadruple treatment is recommended)	-
		-
Asian Pacific (2009)[15]	Standard PPI-based triple therapy	7 d
	(Bismuth-containing quadruple treatment is an alternative)	-
American College (2007)[14]	Standard PPI-based triple therapy OR	14 d
	Bismuth-containing quadruple treatment	10-14 d
	(Sequential therapy may be an alternative)	-
South Korea (2013)[82]	Standard PPI-based triple therapy	7-14 d
	(Bismuth-containing quadruple treatment is an alternative)	7-14 d
Japan (2009)[16]	Standard PPI-based triple therapy	7 d
Canada (2005)[112]	Standard PPI-based triple therapy	14 d
ESPGHAN and NASPGHAN for children (2011)[113]	Standard PPI-based triple therapy	-
	Bismuth-containing quadruple treatment	10-14 d
	Sequential therapy	10 d

PPI: Proton pump inhibitor; ESPGHAN and NASPGHAN: European and North American Societies of Pediatric Gastroenterology Hepatology and Nutrition.