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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 21, 2014; 20(15): 4276-4287
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4276
Table 2 Biomarkers of DNA methylation in the stool of colorectal cancer patients
MarkersSampleSensitivitySpecificityRef.
AGTR1/WNT2/ SLIT2/VIM/SEPT9214 CRC20%-78%86%-100%[33]
25 IBD
39 controls
Vimentin/EYA4/ BMP3/NDRG4CRC67%-100%89%[34]
ESR119 CRC65%81%[35]
38 controls
SLIT260 CRC100%[36]
32 IBD associated CRC
20 HR-IBD25%
65 LR-IBD
28 controls
PHACTR364 CRC66%100%[37]
71 A32%
34 controls
TFPI260 CRC68.3%100%[38]
20 A
30 controls
CNRIP1/FBN/INA/ MAL/SNCA/SPG2078 CRC65%-94%95%-100%[39]
61 A35%-91%
48 controls
SPG209 CRC67%Unknown[40]
MAL/CDKN2A/ MGMT69 CRC55.1%-78.3%96.2%-100%[41]
24 A37.5%-58.3%
19 HP10.5%-26.3%
24 controls
3OST221 CRC72.7%90%[42]
ITGA4/SFRP2/p1630 CRC70%96.8%[43]
25 A72%
21 controls
RARB2/p16/ INK4a/MGMT/APC26 CRC62%100%[44]
20 A40%
16 IBD13%
20 controls
RASSF1/SFRP284 CRC75%89%[45]
27 advanced A44%
29 non-advanced A28%
12 HP25%
4 IC25%
2 UC100%
113 controls
OSMR69 CRC38%95%[46]
81 controls
Vimentin22 CRC41%95%[47]
20 advanced A45%
38 controls
MGMT/hMLH1/ Vimentin60 CRC75%87%[48]
22 advanced A46%
30 non-advanced A70%
37 controls
ITGA413 A69%79%[49]
NDRG475 CRC53%-61%93%-100%[50]
75 controls
GATA475 CRC51%-71%84%-93%[51]
75 controls
TFPI226 CRC76%-89%79%-93%[17]
45 controls
SFRP269 CRC87.0%93%[52]
34 A61.8%
26 HP42.3%
30 controls
SFRP213 A46%100%[53]
6 HP33%
6 controls
Vimentin103 A46%84%[54]
75 controls
Vimentin/DIA42 CRC86%73%[55]
241 controls
CDKN2A/p16/ MSI/long DNA25 CRC64%95%[56]
20 controls
SFRP252 CRC94%93%[57]
10 advanced A70%
11:00 AM36%
8 HP38%
6 UC17%
24 controls
SFRP2/HPP1/ MGMT52 CRC96%96%[58]
10 advanced A80%
11 non-advanced A64%
8 HP38%
6 UC17%
24 controls
Vimentin/DIA40 CRC88%82%[59]
122 controls
ATM/APC/ MGMT/hMLH1/ HLTF/SFRP2/GSTP120 CRC75%90%[60]
30 A68%
30 controls
241 controls
Vimentin74 CRC72%89%[61]
62 A84%
70 controls
Vimentin94 CRC46%90%[62]
198 controls
HIC126 CRC42%98%[63]
13 A31%
9 HP0%
41 controls
CDKN2A/MGMT/ hMLH129 A55%72%[64]
10 HP40%
25 controls
ATM/APC/ MGMT/hMLH1/ HLTF20 CRC70%100%[65]
20 controls
SFRP223 CRC77%-90%77%[66]
26 controls
10 HP40%
25 controls