Inhibition of host immune response in colorectal cancer: Human leukocyte antigen-G and beyond

Figure 1 Human leukocyte antigen-G single nucleotide polymorphisms involved in the biological features of the protein: nucleotide variants in the 5’-3’ untranslated regions may influence human leukocyte antigen-G expression levels by modifying the affinity of gene targeted sequences for transcriptional (5’) or post-transcriptional (3’) factors respectively. Polymorphisms in 5’UTR (fucsia) were previously described by Costa et al[113] those in 3’UTR (light blue) by Castelli et al[19]. In red 3’UTR SNPs involved in HLA-G mRNA stability and availability are highlighted. In orange the only one microRNA with a demostrated functional inhibitory role in the HLA-G expression[134] was highlighted . UTR: Untranslated region; SNPs: Single nucleotide polymorphisms; HLA-G: Human leukocyte antigen-G.