Computational biology approach to uncover hepatitis C virus helicase operation

Figure 1 Molecular architecture of hepatitis C virus helicase. A: Structure of hepatitis C virus (HCV) helicase in ribbon representation (Protein Data Bank code 1A1V). Motor domains I and II are coloured golden and blue, respectively. Domain III is shown in grey. A sulfate ion, shown as beads, is located at the surface of domain I in the proximity of the adenosine-triphosphate (ATP) binding pocket. The short DNA fragment (shown in bead representation) occupies a large cleft separating the motor domains from the third domain; B: Network representation of HCV helicase. The chain of beads representing a single DNA strand is shown in green.