Multipotent role of platelets in inflammatory bowel diseases: A clinical approach

Table 1 Platelet abnormalities in inflammatory bowel disease

Number and morphological changes	Loss of discoid shape
	Acquisition of pseudopodia
	Size increase
	Count increase (reactive thrombocytosis)
	Density increase
	Granular content augmentation
	MPV value decrease
	PDW value increase
	PCT value increase
Other abnormalities
Overproduction and excretion of granular content products	P-selectin, β-TG, PF-4, fibrinogen, vWF, fibrinolytic inhibitors, coagulation, angiogenic and mitogenic factors
Increased incorporation of receptors in PLT membrane	CD40, P-selectin, GP53, GP IIb/IIIa, receptors for chemokines, cytokines and complement components
Overproduction of PLT-derived microparticles
PLT-PLT aggregates formation
Increased PLT-leukocytes formation

β-TG: β-thromboglobulin; GP: Glycoprotein; IBD: Inflammatory bowel disease; MPV: Mean platelet volume; PCT: Plateletcrit; PDW: Platelet distribution width; PF-4: Platelet factor-4; PLT: Platelets; vWF: Von Willebrand factor.