Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

Figure 1 Changes in body weight and energy intake. A: Time-course of body weight. Four-week-old rats were fed a control diet (control group; n = 8) or a high-fat diet (HFD) (n = 16). After 4 wk of feeding, HFD-fed rats were subdivided into two groups (n = 8 per group) and intraperitoneally injected with either 10 μg/kg body weight exenatide [HFD-Ex(+) group] or saline [HFD-Ex(-) group] every day for 12 wk. Rats in the control group were injected with saline. At week 16 of feeding, the body weight was significantly lower in the HFD-Ex(+) group than in the control and HFD-Ex(-) groups. n = 8. ^aP < 0.05 vs other groups; B: Daily energy intake during the treatment period. Energy intake was lower in the HFD-Ex(+) group than in the control or HFD-Ex(-) group.