Measurements of cell proliferation in esophageal and gastric cardia epithelia of subjects in a high incidence area for esophageal cancer

Table 1 Cell proliferation of esophageal and gastric cardia epithelia measured by proliferating cell nuclear antigen, Ki-67 and BudR in symptom-free subjects from high incidence area of northern China

Histological type	PCNA		Ki-67		BudR
	No. of biopsies examined	Positive cells/mm2 (x-± sx-)	No. of biopsies examined	Positive cells/mm2 (x-± sx-)	No. of biopsies examined	Positive cells/mm2 (x-± sx-)
Esophagus
Normal	18	144 ± 16	16	145 ± 20	3	112 ± 56
BCH	136	338 ± 21b	96	308 ± 25b	19	103 ± 9
DYS	21	928 ± 157b	15	773 ± 229b	1	425
Gastric cardia
Normal	9	290 ± 43	6	180 ± 41	-1	-
CSG	17	356 ± 78	12	195 ± 32	-	-
CAG	11	382 ± 85	6	376 ± 134a	-	-
DYS	4	633 ± 111	2	620 ± 143a	-	-

^aSignificantly different from adjacent low-grade lesions; P < 0.05 by ANOVA test.

^bSignificantly different from adjacent low-grade lesions; P < 0.001 by ANOVA test.

¹Not applied for BudR incorporation. PCNA: Proliferating cell nuclear antigen; BCH: Basal cell hyperplasia; DYS: Dysplasia; CSG: Chronic superficial gastritis; CAG: Chronic atrophic gastritis.