Review of the pharmacological management of hepatitis B viral infection before and after liver transplantation

Table 1 Studies of nucleos/tide analogues in patients with hepatitis B related decompensated cirrhosis

Ref.	Fontana et al[47]	Schiff et al[19]	Shim et al[31]	Liaw et al[44]	Chan et al[29]	Hyun et al[49]
Number of patients	154	226	70	45/45/22	114/114	45/41
NA(s) used	LAM	ADV	ETV	TDF/TDF + FTC/ETV	LdT/LAM	ETV/LAM
Baseline data
LAM resistance (%)	0	100	0	18/22/14	0/0	0/0
CTP score	9	NR	8.4	7/7/7	8.1/8.5	9.6/9.5
MELD score	NR	NR	11.5	11/13/10.5	14.7/15.5	16.7/16.1
1-yr data
↓ CTP score ≥ 2 (%)	NR	NR	49	26/48/42	32/39	NR/NR
MELD score ↓	NR	-2	-2.2	-2/-2/-2	-1.0/-2.0	-4.9/-3.7
1-yr survival (%)	84	86	87	96/96/91	94/88	90.7/92.4
Prognostic factors of the outcome	Serum bilirubin and creatinine levels at baseline	NR	NR	NR	NR	Baseline CTP and MELD at 3 mo

ADV: Adefovir; CTP: Child-Turcotte-Pugh; ETV: Entecavir; TDF: Tenofovir; FTC: Emtricitabine; LAM: Lamivudine; LdT: Telbivudine; MELD: Model for end stage liver disease; NR: Not reported; NAs: Nucleostide analogues.