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©2013 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 21, 2013; 19(47): 8873-8879
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8873
Published online Dec 21, 2013. doi: 10.3748/wjg.v19.i47.8873
Table 1 Copy-number altered regions in genomes of hepatocellular carcinoma cell lines
| Cytoband | Start (Mb) | End (Mb) | Known cancer genes | Novel candidates |
| Amplicons | ||||
| 1q21.2-22 | 150.07 | 151.89 | SHC1, CKS1B, ADAM15 | CREB3L4, RAB1, mir190b, S100A14 |
| 3p26.1-25.3 | 6.90 | 9.43 | LMCD1 | |
| 3q26.2-26.31 | 170.07 | 170.24 | ||
| 170.28 | 170.99 | EVI1, MDS1, TERC | ||
| 171.21 | 173.50 | FNDC3B | ||
| 5p15.33-12 | 0.40 | 45.14 | TRIO, AMACR, DAB2 | LPCAT1, SEMA5A, CDH12 |
| 7p22.2-14.3 | 4.15 | 32.10 | RAC1, ETV1, CHN2 | |
| 7p12.1-11.2 | 52.79 | 55.17 | EGFR | |
| 56.00 | 56.53 | |||
| 8p11.21 | 40.44 | 40.62 | ||
| 8q24.21 | 129.21 | 129.29 | ||
| 11q13.2-13.3 | 65.85 | 66.44 | RIN1, BRMS1 | SLC29A2 |
| 67.58 | 67.71 | |||
| 67.91 | 69.35 | LRP5, CCND1, ORAOV1 | FGF4, FGF3 | |
| 12p12.1 | 24.36 | 25.54 | BCAS1, K-ras | |
| 20q13.31 | 53.94 | 53.96 | ||
| Homozygous deletions | ||||
| 2q22.1 | 141.72 | 141.80 | LRP1B | |
| 7q21.11 | 77.96 | 78.04 | MAGI2 | |
| 9p23 | 9.42 | 9.46 | PTPRD | |
| 11.90 | 12.00 | |||
| 9p21.3 | 21.85 | 21.90 | MTAP, CDKN2A | |
| 24.27 | 24.84 | |||
| 13q12.11 | 18.98 | 20.44 | TPTE2, Tg737 | |
- Citation: Gu DL, Chen YH, Shih JH, Lin CH, Jou YS, Chen CF. Target genes discovery through copy number alteration analysis in human hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8873-8879
- URL: https://www.wjgnet.com/1007-9327/full/v19/i47/8873.htm
- DOI: https://dx.doi.org/10.3748/wjg.v19.i47.8873