Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis

doi:10.3748/wjg.v19.i42.7461

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Meta-Analysis

World J Gastroenterol. Nov 14, 2013; 19(42): 7461-7471
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7461

Table 1 Characteristics of the eligible trials included in the meta-analysis

Ref.	Treatment arms	No. of participants	Sex (male/female)	Median age (yr)	PS 0-2/KPS≥50	Pathology (W/M/P/other)	Location of primary tumor(head of pancreas/other)	Jad score
Loehrer et al[9]	RT 50.4 Gy + GEM vs GEM	37	18/19	67	100%	4/6/5/22	12/25
Loehrer et al[9]	RT 50.4 Gy + GEM vs GEM	34	19/15	65.3	100%	6/8/7/13	20/14	3
Klaassen et al[10]	RT 40 Gy + 5FU vs 5FU	44	31/13		100%	NR	NR
Klaassen et al[10]	RT 40 Gy + 5FU vs 5FU	47	22/25	NR	100%	NR	NR	3
Moertel et al[11]	RT 35-40 Gy + saline vs RT 35-40 Gy + 5FU	32	NR	NR	NR	NR	NR
Moertel et al[11]	RT 35-40 Gy + saline vs RT 35-40 Gy + 5FU	32	NR	NR	NR	NR	NR	4
GITSG et al[12]	RT 60 Gy vs RT 60Gy + 5FU vs RT 40 Gy + 5FU	28	12/16	NR	100%	8/17/3/0	10/18
		32	17/15		100%	6/20/6/0	9/23	3
		29	16/13		100%	6/18/5/0	6/23
Cohen et al[13]	RT 59.4 Gy vs RT 59.4 Gy + 5FU + MMC	49	27/22	62	100%	7/21/11/10	NR
Cohen et al[13]	RT 59.4 Gy vs RT 59.4 Gy + 5FU + MMC	55	37/18	64	100%	12/19/17/7	NR	3
Chauffert et al[6]	RT 60 Gy + 5FU + DDP + GEM vs GEM	59	31/28	60	100%	NR	46/13
Chauffert et al[6]	RT 60 Gy + 5FU + DDP + GEM vs GEM	60	34/26	62	100%	NR	40/20	3
Moertel et al[14]	RT 60 Gy vs RT 60 Gy + 5FU vs RT 40 Gy + 5FU	25		54	88%	5/8/2/10	8/17	3
		86		60	95%	20/39/9/14	68/18
		83		61	95%	13/30/9/31	64/19
Sun et al[15]	RT 45-50 Gy + GEM vs GEM	25	32/22	NR	100%	NR	NR	3
Sun et al[15]	RT 45-50 Gy + GEM vs GEM	29	32/22	NR	100%	NR	NR	3
Sun et al[16]	RT 50-60 Gy + GEM vs GEM + DDP	26	33/23	NR	100%	NR	NR	3
Sun et al[16]	RT 50-60 Gy + GEM vs GEM + DDP	30	33/23	NR	100%	NR	NR	3
Wu et al[17]	RT 48-56 Gy vs RT 48-60 Gy + GEM + DDP	31	50/14	57	98%	NR	NR	3
Wu et al[17]	RT 48-56 Gy vs RT 48-60 Gy + GEM + DDP	33	50/14	57	99%	NR	NR	3
Wu et al[18]	RT 60 Gy vs RT 50 Gy + GEM	34	43/27	NR	87%	NR	NR	3
Wu et al[18]	RT 60 Gy vs RT 50 Gy + GEM	36	43/27	NR	90%	NR	NR	3
Ding et al[19]	RT 45-50 Gy + 5FU + GEM vs 5FU + GEM	25	32/22	NR	100%	NR	NR	3
Ding et al[19]	RT 45-50 Gy + 5FU + GEM vs 5FU + GEM	29	32/22	NR	100%	NR	NR	3
Childs et al[20]	RT 35-40 Gy + saline vs RT 35-40 Gy + 5FU	12	11/1	58.8	NR	NR	NR	4
Childs et al[20]	RT 35-40 Gy + saline vs RT 35-40 Gy + 5FU	13	8/5	56.3	NR	NR	NR	4
GITSG et al[21]	RT 54 Gy + 5FU + SMF vs SMF	22	8/14	61	100%	NR	3/18	3
GITSG et al[21]	RT 54 Gy + 5FU + SMF vs SMF	21	8/13	60	100%	NR	3/19	3
Hazel et al[22]	RT 46 Gy + 5FU vs 5FU + CCNU	15	10/5	62	NR	NR	NR	2
Hazel et al[22]	RT 46 Gy + 5FU vs 5FU + CCNU	15	10/5	62	NR	NR	NR	2

W: Well differentiated; M: Moderately differentiated; P: Poorly differentiated; SMF: Streptozocin, mitomycin, and 5-fluorouracil (5FU); NR: No report; GEM: Gemcitabine; RT: radiotherapy alone; MMC: Mitomycin C.

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Citation: Chen Y, Sun XJ, Jiang TH, Mao AW. Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis. World J Gastroenterol 2013; 19(42): 7461-7471
URL: https://www.wjgnet.com/1007-9327/full/v19/i42/7461.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i42.7461

Chen Y, Sun XJ, Jiang TH, Mao AW. Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis. World J Gastroenterol 2013; 19(42): 7461-7471 [PMID: 24259979 DOI: 10.3748/wjg.v19.i42.7461]

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