Quasispecies structure, cornerstone of hepatitis B virus infection: Mass sequencing approach

Figure 4 Secondary structures adopted at the 5’ and 3’ ends of hepatitis B virus pgRNA reported by our group. A: Stem-loop structure of the 5’ with main structural motifs (loops and stems), main codons (1, 14, 15, 28, and 29 of preCore, and 1 of Core gene), and the location of 4-nt primer annealing in the 5’; B: Stem-loop structure of the 3’. The acceptor site (AS), direct repeat region 1 (DR1), and preCore and Core start codons are indicated in the figure. Reproduced from Homs et al[56].