Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

Table 1 Effect of naringenin on microscopic scoring of histopathological sections of colonic tissue of rats with acetic acid-induced ulcerative colitis

Groups	Ulceration	Hyperemia	Necrosis	Edema	Cellular infiltrate	Goblet cell hyperplasia
Control	0	0	0	0	0	0
AA	+++	+++	++++	+++	++++	++
NG25 + AA	++	++	+++	++	+++	++
NG50 + AA	++	++	++	++	+++	+
NG100 + AA	+	+	+	+	++	+
MES + AA	+	+	+	+	+	+

MES: Mesalazine; AA: Acetic acid; NG: Naringenin; NG25: NG 25 mg/kg per day; NG50: 50 mg/kg per day; NG100: 100 mg/kg per day; 0: Normal; +: Mild; ++: Moderate; +++: Sever; ++++: Very sever.