Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease

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Aug 28, 2013 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 28, 2013; 19(32): 5381-5384
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5381

Table 2 Summary of the cases reported in the literature on hepatotoxicity by glucosamine and/or chondroitin sulfate

Ref.	Age (yr) Sex (F/M)	Drugconsumed	Length of consumption	Latency	Jaundice	Peak in AST/ALT (IU/L)	Hypersensitivity	Hepatic failure	Follow-up
Ossendza et al[4]	52/M	Glucosamine	3 wk	4 wk	Yes	263/63	Pruritus, eosinophilia	No	Complete recovery
Smith et al[5]	64/M	Glucosamine/chondroitin sulfate	4 wk	5 wk	Yes	-/1461	-	Yes	Death
	57/F	Glucosamine	4 wk	5 wk	Yes	-/1130	Pruriginous rash	No	Chronic hepatitis
	55/F	Glucosamine	6 mo	8 mo	No	-/175	-	No	Complete recovery
Linnebur et al[6]	71/F	Glucosamine/chondroitin sulfate	7 wk	3 wk	No	600-700/ 00-500	-	No	Complete recovery
	85/F	Glucosamine/chondroitin sulfate	3 wk	3 wk	No	54/37	-	No	Complete recovery
Authors’ cases	71/F	Glucosamine	1 yr	NA	No	182/282	-	No	Liver tests return to pretreatment (basal) values
	77/F	Glucosamine	3 mo	NA	No	161/162	Pruriginous rash	No	Liver tests return to (basa) values

M: Male; F: Female; AST/ALT: Aspartate aminotransferase/ alanine aminotransferase; NA: Not available.

Citation: Cerda C, Bruguera M, Parés A. Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease. World J Gastroenterol 2013; 19(32): 5381-5384
URL: https://www.wjgnet.com/1007-9327/full/v19/i32/5381.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i32.5381