Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors

Table 1 Comparison of clinical background factors at the time of liver biopsy in sustained virological response patients, between F0 + 1 + 2 and F3 + 4 groups n (%)

Parameter		F0 + 1 + 2	F3 + 4	P value
Number	232	182	50
Gender (male)	136 (58.6)	104 (57.1)	32 (64.0)	0.3832
Age (yr)	47.9 ± 12.2	45.9 ± 12.4	55.2 ± 8.3	0.0001
BMI	22.6 ± 3.3	22.7 ± 3.3	22.2 ± 3.6	0.5466
AST (U/L)	55.2 ± 45.9	49.8 ± 46.6	74.5 ± 37.6	0.0007
ALT (U/L)	75.5 ± 62.7	70.5 ± 63.0	93.5 ± 58.9	0.0216
γ-GT (U/L)	62.3 ± 71.8	61.4 ± 76.7	65.8 ± 50.4	0.7048
Platelet count (× 104/μL)	18.8 ± 6.2	20.2 ± 6.0	13.9 ± 3.9	0.0001
Genotype type 1/2	108 (46.5)/ 124 (53.5)	86 (47.2)/ 96 (52.8)	22 (44.0)/ 28 (56.0)	0.6830
AFP (ng/mL)	7.7 ± 13.3	5.4 ± 8.6	15.5 ± 21.4	0.0008
Observation period (yr)	7.5 ± 4.9	7.4 ± 4.7	8.0 ± 5.5	0.4350

These 232 patients were divided into two groups according to the F stage: stages 0, 1, and 2 (F0 + 1 + 2 group, n = 182) and stages 3-4 (F3 + 4 group, n = 50). Comparison of clinical background factors at the time of liver biopsy in SVR patients according to the F stage (F0 + 1 + 2 and F3 + 4) was performed, and the data are shown. The clinical background factors demonstrated that there was a higher level of deterioration of the liver in the F3+4 group as compared to the F0 + 1 + 2 group; Age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and α-fetoprotein (AFP) was higher, and platelet count was lower. The parameters are presented as mean ± SD. AST: Upper limit of the normal range is 38 U/L; ALT: Upper limit of the normal range is 44 U/L; γ-glutamyltransferase (GT): Upper limit of normal is 73 U/L; AFP: Upper limit of normal is 20.0 ng/mL; Platelet count: reference value is 15.0 × 10⁴-35.0 × 10⁴/μL. BMI: Body mass index.