Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism

Table 2 Serum levels of diamine oxidase and D-lactate in a rat model of ischemia/reperfusion injury

Group	DAO (IU/mL)					D-lactate (μg/mL)
	2 h	6 h	24 h	72 h	144 h	2 h	6 h	24 h	72 h	144 h
Sham group	2.08 ± 0.16	2.08 ± 0.75	2.03 ± 0.46	1.95 ± 0.36	2.24 ± 0.62	5.11 ± 0.24	5.30 ± 0.0.44	5.38 ± 0.45	5.46 ± 0.42	5.54 ± 0.69
NS + I/R injury	11.04 ± 0.59b	14.58 ± 2.01b	7.36 ± 1.28b	5.12 ± 0.66b	3.91 ± 0.59b	14.73 ± 1.37b	17.85 ± 1.86b	12.73 ± 0.56b	8.22 ± 1.78	6.54 ± 1.04
BM MSCs + I/R injury	8.16 ± 0.71bd	11.36 ± 1.89bd	5.04 ± 1.04bd	4.93 ± 0.69b	3.55 ± 0.59a	12.62 ± 2.24b	13.40 ± 1.53ab	9.80 ± 1.20bd	6.82 ± 0.80b	6.44 ± 0.83
Anti-TNF-α + I/R injury	-	7.99 ± 1.70d	-	-	-	-	12.77 ± 1.44d	-	-	-
Anti-TNF-αR1-IgG + I/R injury	-	7.83 ± 1.28d	-	-	-	-	12.16 ± 1.47d	-	-	-

All values are mean ± SD (n = 6).

^aP < 0.05,

^bP < 0.01 vs Sham group;

^dP < 0.01 vs the saline (NS) + ischemia/reperfusion (I/R) injury group.