A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes

doi:10.3748/wjg.v19.i20.3007

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May 28, 2013 (publication date) through Sep 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2013; 19(20): 3007-3017
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3007

Table 2 Concentrations of total glutathione, thioredoxin, nitrosothiols, and activity of glutathione peroxidase, malondialdehyde-thiobarbituric acid reactive substances, nitrosothiols, nitrotyrosine, and keratin-18 in the liver of rats

		Day 7	Day 14	Day 30
Glutathione	S	34.3 ± 3.1	33.2 ± 1.4	25.3 ± 1.2^a
34.0 ± 1.3 nmol/mg prt	R	35.1 ± 1.2	33.7 ± 1.0	30.9 ± 1.1^a^c
Thioredoxin	S	14.2 ± 1.0^a	16.3 ± 2.4^a	5.2 ± 0.7
5.6 ± 0.9 nmol/mg prt	R	11.3 ± 1.0^a	14.4 ± 1.0^a	6.2 ± 0.7^c
Nitrosothiols	S	32.9 ± 3.5^a	30.0 ± 2.2^a	13.0 ± 1.2^a
16.8 ± 4.7 pmol/mg prt	R	35.4 ± 2.7^a	27.3 ± 2.2^a^c	15.8 ± 1.5^a^c
MDA-TBA	S	17 ± 4^a	39 ± 8^a	92 ± 10^a
12 ± 3 nmol/L	R	12 ± 3	19 ± 4^a^c	41 ± 9^a^c
Nitrosothiols	S	73 ± 15	79 ± 12^a	88 ± 10^a
62 ± 10 nmol/L	R	67 ± 10	69 ± 10	74 ± 11^a^c
Nitrotyrosine	S	6 ± 2	10 ± 3^a	14 ± 3^a
6 ± 1 nmol/L	R	5 ± 1	5 ± 2^c	10 ± 2^a^c
K-18	S	222 ± 21	233 ± 16^a	289 ± 20^a
198 ± 20 U/L	R	210 ± 10	213 ± 13^c	240 ± 17^a^c
GPx activity	S	9.3 ± 1.2^a	21.1 ± 3.7^a	13.7 ± 1.8^a
4.5 ± 0.4 nmol NADH/min/mg prt	R	6.3 ± 0.9^a,b	20.8 ± 1.4^a	16.6 ± 2.6^a,b

The liver of rats fed a choline-deficient (CD) diet without (S)/with (R) Realsil or a normal choline-supplemented diet (controls). Values from controls are reported in the first column under the parameter. Data are mean ± SD of n = 5 rats per group at each time point.

^aP < 0.05 vs control rats;

^cP < 0.05 vs rats on CD diet without Realsil at the same time point. GPx: Glutathione peroxidase; MDA-TBA: Malondialdehyde-thiobarbituric acid reactive substances; K-18: Keratin-18; prt: Protein.

Citation: Grattagliano I, Diogo CV, Mastrodonato M, de Bari O, Persichella M, Wang DQ, Liquori A, Ferri D, Carratù MR, Oliveira PJ, Portincasa P. A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes. World J Gastroenterol 2013; 19(20): 3007-3017
URL: https://www.wjgnet.com/1007-9327/full/v19/i20/3007.htm
DOI: https://dx.doi.org/10.3748/wjg.v19.i20.3007