Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis

Figure 7 Expression of interleukin-22 and its related proteins in the mouse chronic colitis model. A: The average integrated optical density (IOD) for the immunohistochemistry staining of interleukin (IL)-22, IL-23, and IL-22R1 in mouse ulcerative colitis and normal tissues at different time points: days 40, 80, and 120. The expression of IL-22, IL-22R1, and IL-23 gradually increased with time; B: Western blotting detection of p-STAT3 (S727), total STAT3, Bcl-2, survivin, and cyclin D1 after DSS administration. Expression levels were all normalized to β-actin. All genes showed sustained expression over time.