Increased endothelin receptor B and G protein coupled kinase-2 in the mesentery of portal hypertensive rats

Figure 2 Expression of endothelin B receptor in rat mesentery. Expression of endothelin B receptor (ETBR) in the mesentery of sham-operated rats (A), and common/L on bile duct ligation rats at 2 wk (B) and 4 wk (C). In the mesentery of sham-operated rats, ETBR (green) was mainly expressed in CD31⁺ endothelial cells (red) of the vascular, with weak staining in the microcirculation. With portal pressure rising, ETBR expression was detected in the smooth muscle cells of arterioles and the microcirculation.