Evaluation of the relationship between dietary factors, CagA-positive Helicobacter pylori infection, and RUNX3 promoter hypermethylation in gastric cancer tissue

Table 3 Associations between dietary factors and RUNX3 methylation risk, according to CagA status

	Total subjects		CagA(-) or H. pylori (-)		CagA(+)
	Methylated/unmethylated	OR (95%CI)1	Methylated/unmethylated	OR (95%CI)1	Methylated/unmethylated	OR (95%CI)1
Nuts
Low	36/40	1.0	26/23	1.0	10/17	1.0
High	70/38	1.65 (0.86-3.18)	46/30	1.10 (0.49-2.49)	24/8	4.28 (1.19-15.49)23
Vegetables
Low	65/39	1.0	47/26	1.0	18/13	1.0
High	41/39	0.58 (0.31-1.07)	25/27	0.49 (0.23-1.03)	16/12	0.78 (0.27-2.36)
Fruits
Lo	69/39	1.0	51/31	1.0	18/8	1.0
High	37/39	0.50 (0.27-0.93)3	21/22	0.55 (0.26-1.19)	16/17	0.32 (0.10-1.06)
Meat
Low	39/40	1.0	26/28	1.0	13/12	1.0
High	67/38	1.68 (0.91-3.12)	46/25	1.83 (0.87-3.87)	21/13	1.30 (0.41-4.10)
Egg
Low	32/40	1.0	21/29	1.0	11/11	1.0
High	74/38	2.15 (1.14-4.08)3	51/24	2.64 (1.21-5.75)3	23/14	1.57 (0.48-5.23)
Chicken
Low	34/39	1.0	20/26	1.0	14/13	1.0
High	72/39	1.78 (0.93-3.41)	52/27	2.24 (1.02-4.95)3	20/12	0.95 (0.27-3.39)
Seaweeds
Low	64/39	1.0	43/30	1.0	21/9	1.0
High	42/39	0.63 (0.35-1.16)	29/23	0.89 (0.43-1.87)	13/16	0.23 (0.07-0.79)3
Alliums
Low	66/40	1.0	43/28	1.0	23/11	1.0
High	40/38	0.55 (0.30-1.01)	29/25	1.71 (0.34-1.48)	11/14	0.28 (0.09-0.92)3
Fish
Low	61/39	1.0	40/29	1.0	21/10	1.0
High	45/39	0.69 (0.38-1.27)	32/24	0.89 (0.43-1.85)	13/15	0.44 (0.14-1.33)

¹Adjusted for age, gender, total energy intake;

²Odds ratio (OR) was significantly different according to CagA status in a homogeneity test;

³P value < 0.05 statistically significant difference.