Scolopendra subspinipes mutilans protected the cerulein-induced acute pancreatitis by inhibiting high-mobility group box protein-1

Figure 1 Effects of Scolopendra subspinipes mutilans on inflammation in the pancreas following pancreatitis. A, B: 200 × (A) and 400 × (B) magnification of representative hematoxylin and eosin stained pancreatic sections of control mice and mice pretreated with Scolopendra subspinipes mutilans (SSM) (0.1, 0.5 or 1 g/kg) 1 h before the cerulein (50 μg/kg)-mediated induction of acute pancreatitis (AP); C: Myeloperoxidase (MPO) activity was measured in the pancreas 6 h after completion of the cerulein injections. Data are expressed as U/mg protein. Data are represented as mean ± SE (n = 6 in each group). The results were similar in 3 further experiments. ^aP < 0.05 vs control group, ^cP < 0.05 vs cerulein treatment alone.