Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells

Figure 3 Interleukin-8 involved in gastric cancer cell adhesion, migration and invasion. A: Effect of Interleukin-8 (IL-8) on gastric cancer (GC) cell adhesion to human endothelial cells and extracellular matrix components. Histograms show fold change in the relative OD value of control cells quantified by cell proliferation assay to calculate the mean cellular adhesion capability; B: Effect of IL-8 on GC cell migration tested by wound-healing assays. Histograms show distances of cell migration; C: Effect of IL-8 on GC cell migration tested by Transwell assays. Histograms show fold change in the number of migrated cells vs the control cells; D: Effect of IL-8 on GC cell invasion. Histograms show fold change in the number of invaded cells vs the control cells. Each bar represents the mean ± SD. All experiments were repeated three times with similar results (^aP < 0.05). HUVEC: Human umbilical vein endothelial cell.