Original Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 28, 2012; 18(8): 746-753
Published online Feb 28, 2012. doi: 10.3748/wjg.v18.i8.746
Table 1 Fibrosis tests composed of laboratory parameters
Fibrosis testCalculation
AARAST/ALT
APRI[(AST/ULN)/platelet count (109/L)] × 100
FibroQ(10 × age × AST × PT INR)/(PLT × ALT)
CDSPlatelet count (109/L): > 340 = 0; 280-339 = 1; 220-279 = 2; 160-219 = 3; 100-159 = 4; 40-99 = 5; < 40 = 6
ALT/AST ratio: > 1.7 = 0; 1.2-1.7 = 1; 0.6-1.19 = 2; < 0.6 = 3
APIINR: < 1.1 = 0; 1.1-1.4 = 1; > 1.4 = 2 CDS is the sum of the above (possible value, 0-11)
Age (yr): < 30 = 0; 30-39 = 1; 40-49 = 2; 50-59= 3; 60-69 = 4; > 70 = 5
Platelet count (109/L): ≥ 225 = 0; 200-224 = 1; 175-199 = 2; 150-174 = 3; 125-149 = 4; ≤ 125 = 5
API is the sum of the above (possible value, 0-10)
Pohl scorePositive: AAR ≥ 1 and platelet count < 150 × 109/L
FIB-4 index[Age (yr) × AST (U/L)]/[platelet count (109/L) × ALT (U/L) 1/2]
Lok’s modelLog odds (predicting cirrhosis) = -5.56 to 0.0089 × platelet (× 103/mm3) + 1.26 × AST/ALT ratio + 5.27 × PT INR Predicted probability = exp (log odds)/[1 + exp (log odds)]
AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AAR: AST/ALT ratio; APRI: AST-to-platelet ratio index; API: Age-platelet index; CDS: Cirrhosis discriminant score; ULN: Upper limit of normal; PLT: Posterolateral thoracotomy; PT-INR: Prothrombin time international normalized ratio.