Meta-analysis of laparoscopic vs open liver resection for hepatocellular carcinoma

Table 1 Characteristics of studies included in the meta-analysis

Study	Year	Country	Group	n	Male/female	Age (yr) (mean ± SD)	Matchingb	Study quality
Shimada et al[27]	2001	Japan	LLR	17	15/2	62 ± 9	1,3,4	*****
			OLR	38	24/14	63 ± 79
Laurent et al[28]	2003	France	LLR	13	10/3	62.6 ± 9.5	1,3,4,5	******
			OLR	14	10/4	65.9 ± 5.5
Kaneko et al[29]	2005	Japan	LLR	30	18/12	59 ± 8	1,2,3,4,5	*****
			OLR	28	18/10	61 ± 10
Belli et al[30]	2007	Italy	LLR	23	13/10	59.5 ± 6.84	1,2,3,4,5	*******
			OLR	23	14/9	62.4 ± 7.7
Endo et al[31]	2009	Japan	LLR	10	8/2	72 ± 4	3,4	****
			OLR	11	8/3	64 ± 2
Lai et al[32]	2009	China	LLR	25	18/7	59 (35-79)a	1,3,4	******
			OLR	33	21/12	59 (38-77)a
Sarpel et al[11]	2009	United States	LLR	20	15/5	63.8 ± 10.3	1,3,4	*******
			OLR	56	45/11	58.3 ± 11.0
Aldrighetti et al[33]	2010	Italy	LLR	16	11/5	65 ± 10	1,2,3,4,5	********
			OLR	16	12/4	71 ± 6
Tranchart et al[10]	2010	France	LLR	42	15/27	63.7 ± 13.1	1,2,3,4,5	******
			OLR	42	14/28	65.7 ± 7.1
Nguyen et al[34]	2011	United States	LLR	17	12/5	68	1,3,4,5	*****
			OLR	20	12/8	65
Hu et al[16]	2011	China	LLR	30	20/10	46 ± 12	1,3,4	****
			OLR	30	19/11	48 ± 15
Ker et al[19]	2011	China	LLR	11	92/24	58.31 ± 12.7	1,2	****
			OLR	208	156/52	57.9 ± 11.2
Kim et al[20]	2011	South Korea	LLR	26	18/8	57.84 ± 9.66	1,2,3,4,5	******
			OLR	29	20/9	57.08 ± 9.78
Lee et al[17]	2011	China	LLR	33	24/9	59 (36-85)a	1,2,4	*******
			OLR	50	40/10	58.5 (32-81)a
Truant et al[18]	2011	France	LLR	36	31/5	60.6 ± 10.2	1,2,3,4	*******
			OLR	53	47/6	63.3 ± 7.6

LLR: Laparoscopic liver resection; OLR: Open liver resection.

^aMedian with range;

^b1: Age; 2: American Society of Anesthesiologists physical status score; 3: Presence of cirrhosis; 4: Tumor size; 5: Type of liver resection.