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©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2012; 18(45): 6577-6586
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6577
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6577
Table 2 Clinicopathological characteristics of patients with gastric cancer based on human epidermal growth factor receptor 2 expression, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mutations and Epstein-Barr virus infection n (%)
| HER2 | PIK3CA | EBV | ||||||||
| Positive(n = 20) | Negative(n = 211) | P value | Mutation(n = 20) | Wild type(n = 211) | P value | Positive(n = 18) | Negative(n = 204) | P value | ||
| Sex | Male | 15 (75) | 142 (67) | 0.48 | 13 (65) | 144 (68) | 0.77 | 14 (78) | 138 (68) | 0.38 |
| Female | 5 (25) | 69 (33) | 7 (35) | 70 (32) | 4 (22) | 66 (32) | ||||
| Age | Median | 69 (50-84) | 71 (25-91) | 0.26 | 71 (25-85) | 70 (38-91) | 0.40 | 72 (48-90) | 70 (38-91) | 0.41 |
| Location | Cardias | 10 (50) | 72 (34) | 0.49 | 5 (25) | 77 (36) | 0.31 | 8 (44) | 73 (36) | 0.70 |
| Body | 5 (25) | 57 (27) | 4 (20) | 58 (27) | 5 (28) | 55 (27) | ||||
| Antrum | 5 (25) | 78 (37) | 10 (50) | 73 (35) | 5 (28) | 75 (37) | ||||
| Unknown | 0 | 4 (2) | 1 (5) | 2 (1) | 0 | 1 (0) | ||||
| Depth | T2 | 12 (60) | 113 (54) | 0.48 | 8 (40) | 117 (55) | 0.15 | 12 (67) | 106 (52) | 0.35 |
| T3 | 8 (40) | 84 (40) | 9 (45) | 83 (39) | 6 (33) | 85 (42) | ||||
| T4 | 0 | 14 (6) | 3 (15) | 11 (5) | 0 | 13 (6) | ||||
| L/N meta | N0 | 5 (25) | 60 (28) | 0.71 | 4 (20) | 61 (29) | 0.37 | 3 (17) | 57 (28) | 0.28 |
| N+ | 14 (70) | 144 (68) | 16 (80) | 142 (67) | 14 (77) | 140 (69) | ||||
| N1 | 5 (25) | 68 (32) | 8 (40) | 65 (31) | 8 (44) | 63 (31) | ||||
| N2 | 6 (30) | 50 (24) | 6 (30) | 50 (24) | 2 (11) | 53 (26) | ||||
| N3 | 3 (15) | 26 (12) | 2 (10) | 27 (13) | 4 (22) | 24 (12) | ||||
| Unknown | 1 (5) | 7 (3) | 0 | 8 (4) | 1 (6) | 7 (3) | ||||
| Stage | I | 5 (25) | 44 (21) | 0.89 | 1 (5) | 48 (23) | 0.14 | 3 (17) | 41 (20) | 0.98 |
| II | 3 (15) | 42 (20) | 7 (35) | 38 (18) | 4 (22) | 39 (19) | ||||
| III | 6 (30) | 76 (36) | 8 (40) | 74 (35) | 6 (33) | 75 (37) | ||||
| IV | 5 (25) | 46 (22) | 4 (20) | 47 (22) | 4 (22) | 46 (23) | ||||
| Unknown | 1 (5) | 3 (1) | 0 | 4 (2) | 1 (6) | 3 (1) | ||||
| Lauren | Intestinal | 15 (75) | 98 (46) | 0.05 | 14 (70) | 99 (47) | 0.13 | 5 (28) | 105 (51) | 0.04 |
| histotype | Diffuse | 5 (25) | 107 (51) | 6 (30) | 106 (50) | 13 (72) | 93 (46) | |||
| LELC | 0 | 6 (3) | 2 (10) | 4 (2) | 5 (28) | 0 | ||||
| Others | 0 | 6 (3) | 0 | 6 (3) | 0 | 6 (3) | ||||
| MSI | 2 (10) | 28 (13) | 0.72 | 10 (50) | 20 (9) | < 0.01 | 1 (6) | 26 (13) | 0.36 | |
| pAkt | 16 (84) | 103 (51) | < 0.01 | 12 (63) | 107 (53) | 0.37 | 8 (47) | 103 (52) | 0.69 | |
| 3 yr OS (%) | 29.4 | 59.2 | 0.24 | 57.3 | 56.8 | 0.59 | 57.4 | 57.3 | 0.98 | |
- Citation: Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. World J Gastroenterol 2012; 18(45): 6577-6586
- URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6577.htm
- DOI: https://dx.doi.org/10.3748/wjg.v18.i45.6577