Original Article
Copyright ©2012 Baishideng Publishing Group Co.
World J Gastroenterol. Dec 7, 2012; 18(45): 6577-6586
Published online Dec 7, 2012. doi: 10.3748/wjg.v18.i45.6577
Table 2 Clinicopathological characteristics of patients with gastric cancer based on human epidermal growth factor receptor 2 expression, phosphatidylinositol 3-kinase, catalytic, alpha polypeptide mutations and Epstein-Barr virus infection n (%)
HER2PIK3CAEBV
Positive(n = 20)Negative(n = 211)P valueMutation(n = 20)Wild type(n = 211)P valuePositive(n = 18)Negative(n = 204)P value
SexMale15 (75)142 (67)0.4813 (65)144 (68)0.7714 (78)138 (68)0.38
Female5 (25)69 (33)7 (35)70 (32)4 (22)66 (32)
AgeMedian69 (50-84)71 (25-91)0.2671 (25-85)70 (38-91)0.4072 (48-90)70 (38-91)0.41
LocationCardias10 (50)72 (34)0.495 (25)77 (36)0.318 (44)73 (36)0.70
Body5 (25)57 (27)4 (20)58 (27)5 (28)55 (27)
Antrum5 (25)78 (37)10 (50)73 (35)5 (28)75 (37)
Unknown04 (2)1 (5)2 (1)01 (0)
DepthT212 (60)113 (54)0.488 (40)117 (55)0.1512 (67)106 (52)0.35
T38 (40)84 (40)9 (45)83 (39)6 (33)85 (42)
T4014 (6)3 (15)11 (5)013 (6)
L/N metaN05 (25)60 (28)0.714 (20)61 (29)0.373 (17)57 (28)0.28
N+14 (70)144 (68)16 (80)142 (67)14 (77)140 (69)
N15 (25)68 (32)8 (40)65 (31)8 (44)63 (31)
N26 (30)50 (24)6 (30)50 (24)2 (11)53 (26)
N33 (15)26 (12)2 (10)27 (13)4 (22)24 (12)
Unknown1 (5)7 (3)08 (4)1 (6)7 (3)
StageI5 (25)44 (21)0.891 (5)48 (23)0.143 (17)41 (20)0.98
II3 (15)42 (20)7 (35)38 (18)4 (22)39 (19)
III6 (30)76 (36)8 (40)74 (35)6 (33)75 (37)
IV5 (25)46 (22)4 (20)47 (22)4 (22)46 (23)
Unknown1 (5)3 (1)04 (2)1 (6)3 (1)
LaurenIntestinal15 (75)98 (46)0.0514 (70)99 (47)0.135 (28)105 (51)0.04
histotypeDiffuse5 (25)107 (51)6 (30)106 (50)13 (72)93 (46)
LELC06 (3)2 (10)4 (2)5 (28)0
Others06 (3)06 (3)06 (3)
MSI2 (10)28 (13)0.7210 (50)20 (9)< 0.011 (6)26 (13)0.36
pAkt16 (84)103 (51)< 0.0112 (63)107 (53)0.378 (47)103 (52)0.69
3 yr OS (%)29.459.20.2457.356.80.5957.457.30.98