Current progress in the treatment of chronic hepatitis C

doi:10.3748/wjg.v18.i42.6060

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 42

This Article

(0)

(9961)

(22)

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Review

World J Gastroenterol. Nov 14, 2012; 18(42): 6060-6069
Published online Nov 14, 2012. doi: 10.3748/wjg.v18.i42.6060

Table 2 Sustained virological response rates in phase III clinical trials with hepatitis C virus protease inhibitor-based regimens in treatment-naïve and treatment-experienced patients

Name of trial		SVR
Naïve patients - Treatment group
SPRINT-2
BOC/RGT		63%
BOC44/PR48		66%
PR48		38%
ADVANCE
T12PR		75%
T8PR		69%
PR		44%
ILLUMINATE
T12PR24 (eRVR+)		92%
T12PR48 (eRVR+)		87%
T12PR48 (eRVR-)		64%
< 20 wk		23%
Treatment-experienced patients - Treatment group
RESPOND-2
Prior relapsers	PR48	29%
	BOC/RGT	69%
	BOC44/PR48	75%
Prior partial responders	PR48	7%
	BOC/RGT	40%
	BOC44/PR48	52%
REALIZE
Prior relapsers	PR48	24%
	LIT12PR48	88%
	T12PR48	83%
Prior partial responders	PR48	15%
	LIT12PR48	54%
	T12PR48	59%
Prior null responders	PR48	5%
	LIT12PR48	33%
	T12PR48	29%

BOC: Boceprevir; RGT: Response-guided therapy; P: Pegylated interferon-alfa; R: Ribavirin; T: Telaprevir; eRVR: Extended rapid virological response; LI: Lead-in; SVR: Sustained virological response.

Full Size Table

Citation: Alexopoulou A, Papatheodoridis GV. Current progress in the treatment of chronic hepatitis C. World J Gastroenterol 2012; 18(42): 6060-6069
URL: https://www.wjgnet.com/1007-9327/full/v18/i42/6060.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i42.6060

Alexopoulou A, Papatheodoridis GV. Current progress in the treatment of chronic hepatitis C. World J Gastroenterol 2012; 18(42): 6060-6069 [PMID: 23155334 DOI: 10.3748/wjg.v18.i42.6060]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.