Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line

Table 1 Demographic data of patients, extracted from the published papers (n = 9)

Ref.	Pts	Days of tp	Test confirming infection	Test confirming eradication	Age (yr)		Male (%)		Smokers (%)		Clinic (%)
					L+ A	Q	L + A	Q	L + A	Q	L + A	Q
Nista et al[21]	140	10	UBT and/or biopsy	UBT	47 ± 10	48 ± 10	47	49	NA	NA	UD = 37; DD = 33; RD = 30	UD = 40; DD = 34; RD = 26
Perri et al[29]	113	7	UBT	UBT	46 ± 16	45 ± 15	48	47	17	20	N = 63; OE = 3; G = 9; GU = 3; D = 10;   DU = 9; O = 3	N = 67; OE = 5; G = 2; GU = 0; D = 19; DU = 5; O = 2
Bilardi et al[39]	90 (40)	10	UBT and/or biopsy	UBT	56 ± 10	54 ± 13	30	35	64	52	NA	NA
Gisbert et al[28]	500 (150)	7-10	UBT	UBT	48 ± 131		391		231		FD = 76; DU = 241
Lee et al[80]	126 (23)	7	Rapid urea test	UBT	50 ± 141		631		241		GU = 44; DU = 32; GA = 11; A = 3; F = 1; FD = 9
Wong et al[19]	106 (61)	7	Rapid urea test and/or biopsy	UBT	47 ± 121	45 ± 131	441	421	201	191	N = 64; E = 6; GU = 6; DU = 24	N = 77; E = 8; GU = 0; DU = 15
Zhang et al[37]	95	7			49		NA	NA	NA	NA	GU/DU = 24; G = 62; GA = 14
Jung et al[42]	76	7	Rapid urea test and/or UBT	Rapid urea test or UBT	48 ± 12	50 ± 10	58	58	NA	NA	GU = 39; DU = 32; GA = 10; G = 19	GU = 38; DU = 33; GA = 18; G = 11
Kuo et al[41]	166	7	Rapid urea test and/or biopsy or culture	Rapid urea test and/or biopsy or UBT	50 ± 12	49 ± 14	53	48	14	12	GU = 23; DU = 41; G = 36	GU = 25; DU = 40; G = 35

¹Demographic data were reported together for both arms. In studies including patients after failure of more than one therapy, extrapolated data on patients pre-treated in second-line are reported in parenthesis; in those cases demographic data are referred to the entire study population. Pts: Patients (total number); L + A: Levofloxacin/amoxicillin-based therapy; Days of therapy (tp): Duration of L + A scheme; UBT: Urea breath test; Q: Quadruple standard therapy; UD: Ulcer-like dyspepsia; DD: Dysmotility-like dyspepsia; RD: Reflux-like dyspepsia; N: Normal; OE: Esophagitis; G: Gastritis; GU: Gastric ulcer; D: Duodenitis; O: Other; FD: Functional dyspepsia; DU: Duodenal ulcer; A: Adenoma; E: Erosion; GA: Gastric atrophy; F: Family history; NA: Not available.