Antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline on bile duct ligation induced liver fibrosis in rats

doi:10.3748/wjg.v18.i37.5283

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2012; 18(37): 5283-5288
Published online Oct 7, 2012. doi: 10.3748/wjg.v18.i37.5283

Table 1 Comparision of liver functions

Group	n	ALT (IU/L)	AST (IU/L)	TBIL (μmol/L)	AKP (IU/L)	PT (S)	ALB (g/L)
Normal	10	71.0 ± 32.8	146.0 ± 36.7	1.0 ± 0.8	221.8 ± 96.5	9.3 ± 1.6	38.1 ± 0.9
Model	8	66.9 ± 46.7	472.1 ± 236^a	56.4 ± 53.9^a	299.1 ± 37.4^a	16.6 ± 4.6^a	29.7 ± 9.5^a
BDL + AcSDK	8	70.0 ± 34.9	245.7 ± 92.8^c	6.3 ± 3.3^c	265.4 ± 77.5	11.8 ± 1.0^c	34.0 ± 4.9

^aP < 0.05 vs normal;

^cP < 0.05 vs model. BDL: Bile duct ligation; AcSDK: N-acetyl-seryl-aspartyl-lysyl-proline; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TBIL: Total bilirubin; AKP: Alkaline phosphatase; PT: Prothrombin time; ALB: Albumin.

Citation: Zhang L, Xu LM, Chen YW, Ni QW, Zhou M, Qu CY, Zhang Y. Antifibrotic effect of N-acetyl-seryl-aspartyl-lysyl-proline on bile duct ligation induced liver fibrosis in rats. World J Gastroenterol 2012; 18(37): 5283-5288
URL: https://www.wjgnet.com/1007-9327/full/v18/i37/5283.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i37.5283