Indomethacin but not a selective cyclooxygenase-2 inhibitor inhibits esophageal adenocarcinogenesis in rats

Figure 3 Macroscopic findings. A: Effect of treatment on metaplasia in continuity length. A significant decrease was observed in indomethacin-treated groups compared to control groups (P = 0.007); B: Treatment effect on the percentage of animals that developed metaplasia beyond the anastomosis. Percentage of animals that developed metaplasia beyond the anastomosis was significantly higher in both control and MF-tricyclic groups (P = 0.009 and P = 0.036, respectively); C: Percentage of animals that developed dysplasia; D: Because most animals developed dysplasia, low-to-medium grade vs high-grade dysplasia was analyzed. Percentage of rats that developed high-grade dysplasia was significantly lower in indomethacin groups compared to control groups (P = 0.002). When we analyzed the effect of treatment, we observed lower incidence of neoplasia in the indomethacin group (P = 0.000). MF-tricyclic: 3-(3, 4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2-(5H)-furanone.