Effects of anesthetic methods on preserving anti-tumor T-helper polarization following hepatectomy

Table 4 Comparison of interferon-γ, interleukin-4, interleukin-17, FoxP3 mRNA levels and interferon-γ/interleukin-4 mRNA ratio between G + E and G groups

Variables	G + E group (×105)	G group (×105)	P
IFN-γ
d0	21.84 ± 2.99	16.49 ± 0.84	0.585
d2	50.91 ± 1.46	62.87 ± 2.71	0.096
d7	41.05 ± 1.05	29.36 ± 0.73	0.029
IL-4
d0	47.12 ± 28.65	59.97 ± 15.17	0.651
d2	66.63 ± 18.45	110.12 ± 24.11	< 0.001
d7	31.80 ± 14.59	58.21 ± 5.74	0.224
IL-17
d0	351.29 ± 55.29	386.64 ± 61.88	0.768
d2	406.68 ± 68.21	677.80 ± 133.07	0.171
d7	226.20 ± 18.37	429.94 ± 11.90	0.042
FoxP3
d0	430.38 ± 48.95	384.52 ± 42.19	0.408
d2	468.85 ± 89.81	432.97 ± 44.45	0.338
d7	248.68 ± 58.71	361.01 ± 46.75	0.109
IFN-γ/IL-4 ratio
d0	0.44 ± 0.03	0.39 ± 0.04	0.883
d2	0.80 ± 0.10	0.58 ± 0.03	0.198
d7	1.14 ± 0.08	0.56 ± 0.01	0.003

Student’s t test. G: General anesthesia; E: Epidural block; IFN-γ: Interferon-γ; IL: Interleukin.