Family history influences the early onset of hepatocellular carcinoma

Table 2 Distribution of patients with positive family history by age and tumor staging n (%)

	n	Age (yr, median)	Range	P value
Family members
Father	29	53	29.0-78.0	0.101
Mother	42	48.5	33.0-79.0
Siblings	102	39	30.0-48.0
HBV infection		HBV (+) (n = 136)	HBV (-) (n = 29)
Age	Median (min-max)	52.0 (30.0-78.0)	57.0 (29.0-79.0)	0.065
	< 20	0 (0.0)	0 (0.0)	0.001
	20-29	0 (0.0)	1 (3.4)
	30-39	12 (8.8)	1 (3.4)
	40-49	39 (28.7)	9 (31.0)
	50-59	56 (41.2)	5 (17.5)
	60-69	26 (19.1)	8 (27.6)
	70-79	3 (2.2)	5 (17.2)
	≥ 80	0 (0.0)	0 (0.0)
Stage	1	17 (12.5)	1 (3.4)	0.056
	2	46 (33.8)	8 (27.6)
	3	26 (19.1)	12 (41.4)
	4	47 (33.6)	8 (27.6)
HCV infection		HCV (+) (n = 18)	HCV (-) (n = 147)
Age	Median (min-max)	54.0 (29.0-75.0)	52.0 (30.0-79.0)	0.629
	< 20	0 (0.0)	0 (0.0)	0.026
	20-29	1 (5.9)	0 (0.0)
	30-39	1 (5.9)	12 (8.1)
	40-49	5 (29.4)	43 (29.1)
	50-59	3 (17.6)	58 (39.2)
	60-69	6 (35.3)	28 (18.9)
	70-79	1 (5.9)	7 (4.7)
	≥ 80	0 (0.0)	0 (0.0)
Stage	1	18 (12.2)	0 (0.0)	0.335
	2	49 (33.1)	5 (29.4)
	3	32 (21.6)	6 (35.3)
	4	49 (33.1)	6 (35.3)

HBV: Hepatitis B virus; HCV: Hepatitis C virus; FHx: Family history.