Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats

Figure 6 Photomicrographs representative of angiopoietin-2 immunostaining of gastric sections of the studied groups. A: Sham-operated showing faint expression of angiopoietin-2 (Ang-2); B: Gastric ischemia reperfusion (I/R) group showing extensive cytoplasmic expression of Ang-2 in areas of congestion and damage, and in the submucosa; C: Agmatine (AGM) treated group (100 mg/kg, i.p.), with marked attenuation of Ang-2 expression in intact mucosa; D: Wortmannin (15 μg/kg, i.p.) treated group prior to AGM administration abolished the effect of AGM and the expression of Ang-2 is marked in mucosa and sloughed tissues (× 20 magnification).