Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis

Table 2 Comparison of the thickness of gastric mucous layer, the content of hexosamine, the content of plasma endothelin-1, serum nitric oxide and gastric mucosal prostaglandin 2 in different groups

Group	The thickness of gastric mucous layer (μm)	The content of hexosamine (mg/g protein)	Plasma endothelin-1 (pg/mL)	Serum NO (μmol/L)	Gastric mucosal PGE2 (pg/mg)
Normal control group	86.25 ± 3.21	65.57 ± 3.85	52.19 ± 2.82	30.20 ± 2.39	298.7 ± 9.28
Model control group	66.18 ± 5.11b	21.51 ± 4.54b	74.65 ± 8.84b	17.6 ± 3.37a	163.2 ± 8.84a
Low-dose geranylgeranylacetone	79.43 ± 6.67ac	31.78 ± 5.78ac	35.98 ± 4.78ad	50.60 ± 10.68c	205.7 ± 10.39c
High-dose geranylgeranylacetone	81.34 ± 5.98ac	37.78 ± 4.98ac	26.87 ± 4.87ad	69.10 ± 9.56c	265.5 ± 13.39c

^aP < 0.05,

^bP < 0.01 vs normal control group;

^cP < 0.05,

^dP < 0.01 vs model control group. NO: Nitric oxide; PGE₂: Prostaglandin 2.