Risk for gastric neoplasias in patients with chronic atrophic gastritis: A critical reappraisal

Table 2 Incidence of gastric cancer in patients with chronic atrophic gastritis or pernicious anemia

Author	Year	Country	Study type	Patients	Age, median or range (yr)	GC	Annual incidence of GC, person-year (%)
Patients with chronic atrophic gastritis
Walker et al[25]	1971	Australia	Retrospective	40	40-64	4 (10)	0.6
Ectors et al[26]	1986	United Kingdom	Retrospective	225	-	3 (1.3)	0.1
Tatsuta et al[27]	1993	Japan	Retrospective	654	-	22 (3.4)	0.2
You et al[28]	1999	China	Prospective	20821	35-64	19 (0.9)	0.2
Whiting et al[29]	2002	United Kingdom	Prospective	1042	> 40	12 (11.5)	1.1
Dinis-Ribeiro et al[30]	2004	Portugal	Retrospective	1771	-	4 (2.2)	0.7
Lahner et al[31]	2005	Italy	Prospective	106	22-74	1 (0.9)	0.1
de Vries et al[32]	2008	Netherlands	Retrospective	84 0722	65.7	1035 (1.2)	0.2
Vannella et al[33]	2010	Italy	Retrospective	300	18-78	3 (1)	0.2
Patients with pernicious anemia
Borch et al[34]	1986	Sweden	Prospective	61	-	0	0
Kokkola et al[35]	1998	Finland	Prospective	62	20-73	2 (3.2)	1.10
Sjöblom et al[36]	1993	Finland	Prospective	56	27-78	2 (3.5)	1.20
Armbrecht et al[37]	1990	United Kingdom	Prospective	27	26-81	0	0
Bresky et al[38]	2003	Spain	Prospective	68	-	0	0
Ye et al[39]	2003	Sweden	Retrospective	21 265	74.3	177 (0.8)	0.10
Vannella et al[33]	2010	Italy	Retrospective	129	23-74	2 (1.5)	0.30

¹This number refers to biopsies taken in 144 patients and includes chronic atrophic gastritis (CAG) with type I, II, III intestinal metaplasia;

²this number refers to CAG patients with or without intestinal metaplasia. GC: Gastric cancer.