Aspirin-induced small bowel injuries and the preventive effect of rebamipide

Table 1 No. of healthy subjects presenting small bowel injuries following a 4 wk regimen of low dose aspirin in the placebo group and evaluation of preventive efficacy (n = 11)

	Jejunum			Ileum
	Pre-test	1 wk	4 wk	Pre-test	1 wk	4 wk
Placebo group
Multiple erosion (n)	0	1	1	0	6b	4a
Ulcer (n)	0	0	0	0	0	3
Mucosal break (n)	0	1	1	0	6b	7b
Rebamipide group
Mucosal break (n)	0	0	1	0	1c	2c

Multiple erosion (n): No. of subjects with multiple erosions in jejunum or ileum; Ulcer (n): No. of subjects with ulcer in jejunum or ileum; Mucosal break (n): No. of subjects with multiple erosion and/or ulcer in jejunum or ileum. Statistical analysis was performed by Mann Whitney’s U test, compared to before administration vs 1 wk and 4 wk.

^aP < 0.05;

^bP < 0.01;

^cP < 0.05 compared with placebo and rebamipide group.