Serum leptin and ghrelin in chronic hepatitis C patients with steatosis

Table 6 Multiple logistic regression derived odds ratios and 95% CIs for response to hepatitis C virus therapy among patients infected with hepatitis C virus genotype-3 with respect to hepatic steatosis, and leptin and ghrelin concentrations at baseline and at end of follow-up

Variable	Category or increment	ORs	95% CIs	P-value
At baseline
Hepatic steatosis	1 level more	1.04	0.19-5.55	0.97
Leptin	10 ng/mL more	0.64	0.18-2.24	0.49
Ghrelin	0.1 ng/mL more	1.11	0.90-1.49	0.32
HOMA-IR	1 level more	0.13	0.02-0.68	0.02
Alternatively introduced variables
Fibrosis	1 level more	0.16	0.02-0.11	0.06
Leptin	10 ng/mL more	1.22	0.37-4.08	0.74
Ghrelin	0.1 ng/mL more	1.22	0.90-1.65	0.16
HOMA-IR	1 level more	0.16	0.03-0.83	0.03
At end of follow-up
Hepatic steatosis	1 level more	1.77	0.39-7.95	0.46
Leptin	10 ng/mL more	0.40	0.10-1.55	0.18
Ghrelin	0.1 ng/mL more	1.00	0.74-1.22	0.76
HOMA-IR	1 level more	0.10	0.02-0.59	0.01
Alternatively introduced variables
Fibrosis	1 level more	0.40	0.08-1.52	0.16
Leptin	10 ng/mL more	0.70	0.22-2.18	0.54
Ghrelin	0.1 ng/mL more	1.00	0.74-1.35	0.85
HOMA-IR	1 level more	0.14	0.03-0.71	0.02

CI: Confidence interval; HOMA-IR: Homeostasis model assessment insulin resistance; ORs: Odds ratios.